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Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain

The Mecp2 gene has been shown to be mutated in most cases of human Rett syndrome, and mouse models deleted for the ortholog have been generated. Lineage-specific deletion of the gene indicated that the Rett-like phenotype is caused by Mecp2 deficiency in neurons. Biochemical evidence suggests that M...

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Bibliografiske detaljer
Main Authors: Tudor, Matthew, Akbarian, Schahram, Chen, Richard Z., Jaenisch, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137752/
https://ncbi.nlm.nih.gov/pubmed/12432090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242566899
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