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Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome

Rett Syndrome (RTT) is a devastating neurological disorder that is caused by mutations in the MECP2 gene. Mecp2-mutant mice have been used as a model system to study the disease mechanism. Our previous work has suggested that MeCP2 malfunction in neurons is the primary cause of RTT in the mouse. How...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dani, Vardhan S., Chang, Qiang, Maffei, Arianna, Turrigiano, Gina G., Jaenisch, Rudolf, Nelson, Sacha B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1194957/
https://ncbi.nlm.nih.gov/pubmed/16116096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506071102
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