Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

Rett syndrome (RTT) arises from loss-of-function mutations in methyl-CpG binding protein 2 gene (Mecp2), but fundamental aspects of its physiological mechanisms are unresolved. Here, by whole-cell recording of synaptic responses in MeCP2 mutant mice in vivo, we show that visually driven excitatory a...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Banerjee, Abhishek, Rikhye, Rajeev V., Breton-Provencher, Vincent, Tang, Xin, Li, Chenchen, Li, Keji, Runyan, Caroline A., Fu, Zhanyan, Jaenisch, Rudolf, Sur, Mriganka
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135376/
https://ncbi.nlm.nih.gov/pubmed/27803317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615330113
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