Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis.

We have developed a real-time quantitative PCR assay to measure the concentration of fetal DNA in maternal plasma and serum. Our results show that fetal DNA is present in high concentrations in maternal plasma, reaching a mean of 25.4 genome equivalents/ml (range 3.3-69. 4) in early pregnancy and 29...

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Autores principales: Lo, Y M, Tein, M S, Lau, T K, Haines, C J, Leung, T N, Poon, P M, Wainscoat, J S, Johnson, P J, Chang, A M, Hjelm, N M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377040/
https://ncbi.nlm.nih.gov/pubmed/9529358
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