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Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups

The functional groups found among the RNA bases and in the phosphoribose backbone represent a limited repertoire from which to construct a ribozyme active site. This work investigates the possibility that simple RNA phosphodiester and hydroxyl functional groups could catalyze amide bond synthesis. R...

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Detalhes bibliográficos
Main Authors: Chamberlin, Stacy I., Merino, Edward J., Weeks, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137480/
https://ncbi.nlm.nih.gov/pubmed/12403820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212527799
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