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RNA-assisted catalysis in a protein enzyme: The 2′-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase
Aminoacyl-tRNA synthetases (aaRSs) join amino acids to 1 of 2 terminal hydroxyl groups of their cognate tRNAs, thereby contributing to the overall fidelity of protein synthesis. In class II histidyl-tRNA synthetase (HisRS) the nonbridging S(p)-oxygen of the adenylate is a potential general base for...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584683/ https://ncbi.nlm.nih.gov/pubmed/18997014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804247105 |
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