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The Bloom’s syndrome helicase stimulates the activity of human topoisomerase IIIα

Bloom’s syndrome (BS) is a disorder associated with chromosomal instability and a predisposition to the development of cancer. The BS gene product, BLM, is a DNA helicase of the RecQ family that forms a complex in vitro and in vivo with topoisomerase IIIα. Here, we show that BLM stimulates the abili...

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書目詳細資料
Main Authors: Wu, Leonard, Hickson, Ian D.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC137159/
https://ncbi.nlm.nih.gov/pubmed/12433984
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