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Identification of critical amino acid residues on human dihydrofolate reductase protein that mediate RNA recognition
Previous studies have shown that human dihydrofolate reductase (DHFR) acts as an RNA-binding protein, in which it binds to its own mRNA and, in so doing, results in translational repression. In this study, we used RNA gel mobility shift and nitrocellulose filter-binding assays to further investigate...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
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Oxford University Press
2002
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137126/ https://ncbi.nlm.nih.gov/pubmed/12384595 |
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