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Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity
RNA interference (RNAi) is a process by which short interfering RNAs (siRNAs) direct the degradation of complementary single-strand RNAs. In this study, we investigated the effects of full-strand phosphorothioate (PS) backbone and 2′-O-methyl (2′-OMe) sugar modifications on RNAi-mediated silencing....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Copyright 2006 by RNA Society
2006
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370895/ https://ncbi.nlm.nih.gov/pubmed/16301602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2150806 |
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