Effect of manganese on in vitro replication of damaged DNA catalyzed by the herpes simplex virus type-1 DNA polymerase

In vitro bypass of damaged DNA by replicative DNA polymerases is usually blocked by helix-distorting or bulky DNA lesions. In this study, we report that substitution of the divalent metal ion Mg(2+) with Mn(2+) promotes quantitative replication of model DNA substrates containing the major cisplatin...

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Hauptverfasser: Villani, Giuseppe, Le Gac, Nicolas Tanguy, Wasungu, Luc, Burnouf, Dominique, Fuchs, Robert P., Boehmer, Paul E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137087/
https://ncbi.nlm.nih.gov/pubmed/12140316
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