Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades mRNAs containing nonsense codons, and regulates the expression of naturally occurring transcripts. While NMD is not essential in yeast or nematodes, UPF1, a key NMD effector, is essential in mice. Here we show that NMD compon...

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Main Authors: REHWINKEL, JAN, LETUNIC, IVICA, RAES, JEROEN, BORK, PEER, IZAURRALDE, ELISA
格式: Artigo
語言:Inglês
出版: Copyright 2005 by RNA Society 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370837/
https://ncbi.nlm.nih.gov/pubmed/16199763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2160905
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