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In vitro selection of ribozymes dependent on peptides for activity
A peptide-dependent ribozyme ligase (aptazyme ligase) has been selected from a random sequence population based on the small L1 ligase. The aptazyme ligase is activated > 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Copyright 2004 by RNA Society
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370523/ https://ncbi.nlm.nih.gov/pubmed/14681590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5900204 |
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