5′ Exon replacement and repair by spliceosome-mediated RNA trans-splicing

Spliceosome-mediated RNA trans-splicing (SMaRT) has been used previously to reprogram mutant endogenous CFTR and factor VIII mRNAs in human epithelial cell and tissue models and knockout mice, respectively. Those studies used 3′ exon replacement (3′ER); a process in which the distal portion of RNA i...

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Main Authors: MANSFIELD, S. GARY, CLARK, REBECCA HAWKINS, PUTTARAJU, M., KOLE, JOLANTA, COHN, JONATHAN A., MITCHELL, LLOYD G., GARCIA-BLANCO, MARIANO A.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2003 by RNA Society 2003
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Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370493/
https://ncbi.nlm.nih.gov/pubmed/13130143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5101903
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