Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) is caused by mutations in the MAPT gene, encoding the tau protein that accumulates in intraneuronal lesions in a number of neurodegenerative diseases. Several FTDP-17 mutations affect alternative splicing and result in exces...

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Autors principals: Rodriguez-Martin, Teresa, Anthony, Karen, Garcia-Blanco, Mariano A., Mansfield, S. Gary, Anderton, Brian H., Gallo, Jean-Marc
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722988/
https://ncbi.nlm.nih.gov/pubmed/19498037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp264
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