Gene silencing using micro-RNA designed hairpins.

During RNA interference (RNAi), long dsRNA is processed to approximately 21 nt duplexes, short interfering RNAs (siRNAs), which silence genes through a mRNA degradation pathway. Small temporal RNAs (stRNAs) and micro-RNAs (miRNAs) are approximately 21 nt RNAs that are processed from endogenously enc...

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Bibliographic Details
Main Authors: McManus, Michael T, Petersen, Christian P, Haines, Brian B, Chen, Jianzhu, Sharp, Phillip A
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370301/
https://ncbi.nlm.nih.gov/pubmed/12088155
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