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RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

Influenza A virus causes widespread infection in the human respiratory tract, but existing vaccines and drug therapy are of limited value. Here we show that short interfering RNAs (siRNAs) specific for conserved regions of the viral genome can potently inhibit influenza virus production in both cell...

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Detalhes bibliográficos
Main Authors: Ge, Qing, McManus, Michael T., Nguyen, Tam, Shen, Ching-Hung, Sharp, Phillip A., Eisen, Herman N., Chen, Jianzhu
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151407/
https://ncbi.nlm.nih.gov/pubmed/12594334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437841100
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