Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein.

The polypyrimidine tract binding protein (PTB, or hnRNP I) contains four RNA-binding domains of the ribonucleoprotein fold type (RRMs 1, 2, 3, and 4), and mediates the negative regulation of alternative splicing through sequence-specific binding to intronic splicing repressor elements. To assess the...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Haiying, Zhang, Wenqing, Reed, Robyn B, Liu, Weiqun, Grabowski, Paula J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2002
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370238/
https://ncbi.nlm.nih.gov/pubmed/11911361
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