Modulation of Adenovirus Vector Tropism via Incorporation of Polypeptide Ligands into the Fiber Protein

The efficacy of adenovirus (Ad)-based gene therapy might be significantly improved if viral vectors capable of tissue-specific gene delivery could be developed. Previous attempts to genetically modify the tropism of Ad vectors have been only partially successful, largely due to the limited repertoir...

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Bibliographic Details
Main Authors: Belousova, Natalya, Krendelchtchikova, Valentina, Curiel, David T., Krasnykh, Victor
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC136983/
https://ncbi.nlm.nih.gov/pubmed/12163581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8621-8631.2002
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