Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function

The anti-angiogenic activity of endostatin (ES) depends on interactions with heparan sulfate (HS). In the present study, intact HS chains of ≥15 kDa bound quantitatively to ES whereas N-sulfated HS decasaccharides, with affinity for several fibroblast growth factor (FGF) species, failed to bind. Ins...

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Main Authors: Kreuger, Johan, Matsumoto, Taro, Vanwildemeersch, Maarten, Sasaki, Takako, Timpl, Rupert, Claesson-Welsh, Lena, Spillmann, Dorothe, Lindahl, Ulf
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136942/
https://ncbi.nlm.nih.gov/pubmed/12456637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf638
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