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Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function
The anti-angiogenic activity of endostatin (ES) depends on interactions with heparan sulfate (HS). In the present study, intact HS chains of ≥15 kDa bound quantitatively to ES whereas N-sulfated HS decasaccharides, with affinity for several fibroblast growth factor (FGF) species, failed to bind. Ins...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136942/ https://ncbi.nlm.nih.gov/pubmed/12456637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf638 |
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