Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function

The anti-angiogenic activity of endostatin (ES) depends on interactions with heparan sulfate (HS). In the present study, intact HS chains of ≥15 kDa bound quantitatively to ES whereas N-sulfated HS decasaccharides, with affinity for several fibroblast growth factor (FGF) species, failed to bind. Ins...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Kreuger, Johan, Matsumoto, Taro, Vanwildemeersch, Maarten, Sasaki, Takako, Timpl, Rupert, Claesson-Welsh, Lena, Spillmann, Dorothe, Lindahl, Ulf
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136942/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12456637/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf638
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