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Ablation of the spindle assembly checkpoint by a compound targeting Mps1

The spindle assembly checkpoint ensures accurate chromosome segregation by delaying anaphase initiation until all chromosomes are properly attached to the mitotic spindle. Here, we show that the previously reported c-Jun amino-terminal kinase (JNK) inhibitor SP600125 effectively disrupts spindle che...

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Detalhes bibliográficos
Main Authors: Schmidt, Marc, Budirahardja, Yemima, Klompmaker, Rob, Medema, René H
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369161/
https://ncbi.nlm.nih.gov/pubmed/16113653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400483
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