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Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ligase required for ubiquitin-dependent proteolysis of cell-cycle-regulatory proteins, including mitotic cyclins and securin/Pds1. Regulation of APC/C activity and substrate recognition, mediated by the coactivators Cdc20 and Cdh1...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369160/ https://ncbi.nlm.nih.gov/pubmed/16113654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400482 |
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