Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides

The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chrom...

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Detalhes bibliográficos
Main Authors: Coull, Jason J., He, Guocheng, Melander, Christian, Rucker, Victor C., Dervan, Peter B., Margolis, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136904/
https://ncbi.nlm.nih.gov/pubmed/12414976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.23.12349-12354.2002
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