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Binding-Linked Protonation of a DNA Minor-Groove Agent
The energetics for binding of a diphenyl diamidine antitrypanosomal agent CGP 40215A to DNA have been studied by spectroscopy, isothermal titration calorimetry, and surface plasmon resonance biosensor methods. Both amidines are positively charged under experimental conditions, but the linking group...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Biophysical Society
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367283/ https://ncbi.nlm.nih.gov/pubmed/16299076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.071381 |
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