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Binding-Linked Protonation of a DNA Minor-Groove Agent

The energetics for binding of a diphenyl diamidine antitrypanosomal agent CGP 40215A to DNA have been studied by spectroscopy, isothermal titration calorimetry, and surface plasmon resonance biosensor methods. Both amidines are positively charged under experimental conditions, but the linking group...

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Bibliografske podrobnosti
Main Authors: Nguyen, Binh, Stanek, Jaroslav, Wilson, W. David
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367283/
https://ncbi.nlm.nih.gov/pubmed/16299076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.071381
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