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The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran
Transforming growth factor beta (TGF-β) receptors phosphorylate Smad3 and induce its nuclear import so it can regulate gene transcription. Smad3 can return to the cytoplasm to propagate further cycles of signal transduction or to be degraded. We demonstrate that Smad3 is exported by a constitutive m...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367208/ https://ncbi.nlm.nih.gov/pubmed/16449645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1318-1332.2006 |
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