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DNA Polymerase η, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation
DNA polymerase η (PolH) is the product of the xeroderma pigmentosum variant (XPV) gene and a well-characterized Y-family DNA polymerase for translesion synthesis. Cells derived from XPV patients are unable to faithfully bypass UV photoproducts and DNA adducts and thus acquire genetic mutations. Here...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2006
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367184/ https://ncbi.nlm.nih.gov/pubmed/16449651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1398-1413.2006 |
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