Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

DNA polymerase η carries out translesion synthesis past UV photoproducts and is deficient in xeroderma pigmentosum (XP) variants. We report that polη is mostly localized uniformly in the nucleus but is associated with replication foci during S phase. Following treatment of cells with UV irradiation...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Kannouche, Patricia, Broughton, Bernard C., Volker, Marcel, Hanaoka, Fumio, Mullenders, Leon H.F., Lehmann, Alan R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2001
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157773/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.187501
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