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Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

DNA polymerase η carries out translesion synthesis past UV photoproducts and is deficient in xeroderma pigmentosum (XP) variants. We report that polη is mostly localized uniformly in the nucleus but is associated with replication foci during S phase. Following treatment of cells with UV irradiation...

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Autores principales: Kannouche, Patricia, Broughton, Bernard C., Volker, Marcel, Hanaoka, Fumio, Mullenders, Leon H.F., Lehmann, Alan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC312610/
https://ncbi.nlm.nih.gov/pubmed/11157773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.187501
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