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Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

DNA polymerase η carries out translesion synthesis past UV photoproducts and is deficient in xeroderma pigmentosum (XP) variants. We report that polη is mostly localized uniformly in the nucleus but is associated with replication foci during S phase. Following treatment of cells with UV irradiation...

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Sonraí bibleagrafaíochta
Foilsithe in:Genes Dev
Príomhchruthaitheoirí: Kannouche, Patricia, Broughton, Bernard C., Volker, Marcel, Hanaoka, Fumio, Mullenders, Leon H.F., Lehmann, Alan R.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Cold Spring Harbor Laboratory Press 2001
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312610/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157773/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.187501
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