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Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

DNA polymerase η carries out translesion synthesis past UV photoproducts and is deficient in xeroderma pigmentosum (XP) variants. We report that polη is mostly localized uniformly in the nucleus but is associated with replication foci during S phase. Following treatment of cells with UV irradiation...

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Udgivet i:Genes Dev
Principais autores: Kannouche, Patricia, Broughton, Bernard C., Volker, Marcel, Hanaoka, Fumio, Mullenders, Leon H.F., Lehmann, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312610/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157773/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.187501
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