The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Beta Interferon mRNA and Blocks the Host Innate Immune Response

We have previously shown that the leader proteinase (L(pro)) of foot-and-mouth disease virus (FMDV) blocks cap-dependent mRNA translation and that a genetically engineered FMDV lacking the leader proteinase coding region (A12-LLV2) is attenuated in cell culture and susceptible animals. The attenuate...

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Detalhes bibliográficos
Main Authors: de los Santos, Teresa, de Avila Botton, Sonia, Weiblen, Rudi, Grubman, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367153/
https://ncbi.nlm.nih.gov/pubmed/16439546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.4.1906-1914.2006
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