The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.

The foot-and-mouth disease virus (FMDV) leader (L) proteinase has only two known functions: (i) autocatalytic removal from the N terminus of the viral polyprotein and (ii) cleavage of the p220 subunit of the eukaryotic initiation factor 4F complex, which helps to shut off host protein synthesis. Cle...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Piccone, M E, Rieder, E, Mason, P W, Grubman, M J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7636982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.9.5376-5382.1995
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