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Three-Dimensional Visualization of FKBP12.6 Binding to an Open Conformation of Cardiac Ryanodine Receptor

The cardiac isoform of the ryanodine receptor (RyR2) from dog binds predominantly a 12.6-kDa isoform of the FK506-binding protein (FKBP12.6), whereas RyR2 from other species binds both FKBP12.6 and the closely related isoform FKBP12. The role played by FKBP12.6 in modulating calcium release by RyR2...

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Autori principali: Sharma, Manjuli Rani, Jeyakumar, Loice H., Fleischer, Sidney, Wagenknecht, Terence
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367015/
https://ncbi.nlm.nih.gov/pubmed/16214874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.063503
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