Effect of Protein Binding on Ultrafast DNA Dynamics: Characterization of a DNA:APE1 Complex

Synthetic oligonucleotides with a fluorescent coumarin group replacing a basepair have been used in recent time-resolved Stokes-shift experiments to measure DNA dynamics on the femtosecond to nanosecond timescales. Here, we show that the APE1 endonuclease cleaves such a modified oligonucleotide at t...

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Autors principals: Sen, Sobhan, Paraggio, Nicole A., Gearheart, Latha A., Connor, Ellen E., Issa, Ala, Coleman, Robert S., Wilson, David M., Wyatt, Michael D., Berg, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: Biophysical Society 2005
Matèries:
Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366978/
https://ncbi.nlm.nih.gov/pubmed/16199493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.062695
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