Capturing Snapshots of APE1 Processing DNA Damage

DNA apurinic-apyrimidinic (AP) sites are prevalent non-coding threats to genomic stability and are processed by AP endonuclease 1 (APE1). APE1 incises the AP-site phosphodiester backbone, generating a DNA repair intermediate that is potentially cytotoxic. The molecular events of the incision reactio...

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Bibliografske podrobnosti
izdano v:Nat Struct Mol Biol
Main Authors: Freudenthal, Bret D., Beard, William A., Cuneo, Matthew J., Dyrkheeva, Nadezhda S., Wilson, Samuel H.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654669/
https://ncbi.nlm.nih.gov/pubmed/26458045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3105
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