Hexadecylphosphocholine (Miltefosine) Has Broad-Spectrum Fungicidal Activity and Is Efficacious in a Mouse Model of Cryptococcosis

The alkyl phosphocholine drug miltefosine is structurally similar to natural substrates of the fungal virulence determinant phospholipase B1 (PLB1), which is a potential drug target. We determined the MICs of miltefosine against key fungal pathogens, correlated antifungal activity with inhibition of...

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Bibliografiske detaljer
Main Authors: Widmer, Fred, Wright, Lesley C., Obando, Daniel, Handke, Rosemary, Ganendren, Ranjini, Ellis, David H., Sorrell, Tania C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366877/
https://ncbi.nlm.nih.gov/pubmed/16436691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.414-421.2006
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