Limited Activity of Miltefosine in Murine Models of Cryptococcal Meningoencephalitis and Disseminated Cryptococcosis

Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections. Our objective was to further evaluate the in vivo efficacy of miltefosine in experimental in vivo mode...

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Main Authors: Wiederhold, Nathan P., Najvar, Laura K., Bocanegra, Rosie, Kirkpatrick, William R., Sorrell, Tania C., Patterson, Thomas F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553737/
https://ncbi.nlm.nih.gov/pubmed/23165465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01624-12
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