The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis

Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Koselny, Kristy, Green, Julianne, DiDone, Louis, Halterman, Justin P., Fothergill, Annette W., Wiederhold, Nathan P., Patterson, Thomas F., Cushion, Melanie T., Rappelye, Chad, Wellington, Melanie, Krysan, Damian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118990/
https://ncbi.nlm.nih.gov/pubmed/27645246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01061-16
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