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Molecular and Cellular Barriers Limiting the Effectiveness of Antisense Oligonucleotides
Antisense oligonucleotides present a powerful means to inhibit expression of specific genes, but their effectiveness is limited by factors including cellular delivery, biochemical attack, and poor binding to target. We have developed a systems model of the processes required for an antisense oligonu...
Gorde:
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
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Biophysical Society
2005
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366730/ https://ncbi.nlm.nih.gov/pubmed/16055530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.054080 |
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