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Interplay of polyethyleneimine molecular weight and oligonucleotide backbone chemistry in the dynamics of antisense activity

The widespread utilization of gene silencing techniques, such as antisense, is impeded by the poor cellular delivery of oligonucleotides (ONs). Rational design of carriers for enhanced ON delivery demands a better understanding of the role of the vector on the extent and time course of antisense eff...

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Detalhes bibliográficos
Main Authors: Sundaram, Sumati, Lee, Li Kim, Roth, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1935005/
https://ncbi.nlm.nih.gov/pubmed/17576672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm450
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