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The Approach to the Michaelis Complex in Lactate Dehydrogenase: The Substrate Binding Pathway
We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase by characterizing the binding kinetics and thermodynamics of oxamate (a substrate mimic) to the binary lactate dehydrogenase/NADH complex over multiple timescales, from nanoseconds to tens of millisecon...
में बचाया:
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Biophysical Society
2005
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366705/ https://ncbi.nlm.nih.gov/pubmed/15980172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.062604 |
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