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Conformational heterogeneity within the Michaelis complex of lactate dehydrogenase
A series of isotope edited IR measurements, both static as well as temperature jump relaxation spectroscopy, are performed on lactate dehydrogenase (LDH) to determine the ensemble of structures available to its Michaelis complex. There clearly has been a substantial reduction in the number of states...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111758/ https://ncbi.nlm.nih.gov/pubmed/21568287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp2015929 |
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