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The Approach to the Michaelis Complex in Lactate Dehydrogenase: The Substrate Binding Pathway

We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase by characterizing the binding kinetics and thermodynamics of oxamate (a substrate mimic) to the binary lactate dehydrogenase/NADH complex over multiple timescales, from nanoseconds to tens of millisecon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McClendon, Sebastian, Zhadin, Nick, Callender, Robert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Biophysical Society 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366705/
https://ncbi.nlm.nih.gov/pubmed/15980172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.062604
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