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Amino Acid Substitutions in the Pore of the Ca(V)1.2 Calcium Channel Reduce Barium Currents without Affecting Calcium Currents
Ba(2+) currents through Ca(V)1.2 Ca(2+) channels are typically twice as large as Ca(2+) currents. Replacing Phe-1144 in the pore-loop of domain III with glycine and lysine, and Tyr-1152 with lysine, reduces whole-cell G(Ba)/G(Ca) from 2.2 (wild-type) to 0.95, 1.21, and 0.90, respectively. Whole-cell...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1366677/ https://ncbi.nlm.nih.gov/pubmed/15980164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.058875 |
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