Mechanisms Responsible for ω-Pore Currents in Ca(v) Calcium Channel Voltage-Sensing Domains

Mutations of positively charged amino acids in the S4 transmembrane segment of a voltage-gated ion channel form ion-conducting pathways through the voltage-sensing domain, named ω-current. Here, we used structure modeling and MD simulations to predict pathogenic ω-currents in Ca(V)1.1 and Ca(V)1.3 C...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Monteleone, Stefania, Lieb, Andreas, Pinggera, Alexandra, Negro, Giulia, Fuchs, Julian E., Hofer, Florian, Striessnig, Jörg, Tuluc, Petronel, Liedl, Klaus R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627182/
https://ncbi.nlm.nih.gov/pubmed/28978442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.010
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