Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Hepatic steatosis is a core feature of the metabolic syndrome and type 2 diabetes and leads to hepatic insulin resistance. Malonyl-CoA, generated by acetyl-CoA carboxylases 1 and 2 (Acc1 and Acc2), is a key regulator of both mitochondrial fatty acid oxidation and fat synthesis. We used a diet-induce...

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Autori principali: Savage, David B., Choi, Cheol Soo, Samuel, Varman T., Liu, Zhen-Xiang, Zhang, Dongyan, Wang, Amy, Zhang, Xian-Man, Cline, Gary W., Yu, Xing Xian, Geisler, John G., Bhanot, Sanjay, Monia, Brett P., Shulman, Gerald I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366503/
https://ncbi.nlm.nih.gov/pubmed/16485039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27300
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