Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Alterations in mitochondrial function have been implicated in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unclear whether the reduced mitochondrial function is a primary or acquired defect in this process. To determine whether primary defects in mitochondrial β-oxidati...

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Hlavní autoři: Zhang, Dongyan, Liu, Zhen-Xiang, Choi, Cheol Soo, Tian, Liqun, Kibbey, Richard, Dong, Jianying, Cline, Gary W., Wood, Philip A., Shulman, Gerald I.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040460/
https://ncbi.nlm.nih.gov/pubmed/17940018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707060104
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