A Single Mutation in the Carboxy Terminus of Reovirus Outer-Capsid Protein σ3 Confers Enhanced Kinetics of σ3 Proteolysis, Resistance to Inhibitors of Viral Disassembly, and Alterations in σ3 Structure

Mammalian reoviruses undergo acid-dependent proteolytic disassembly within endosomes, resulting in formation of infectious subvirion particles (ISVPs). ISVPs are obligate intermediates in reovirus disassembly that mediate viral penetration into the cytoplasm. The initial biochemical event in the reo...

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Detalhes bibliográficos
Main Authors: Wilson, Gregory J., Nason, Emma L., Hardy, Charles S., Ebert, Daniel H., Wetzel, J. Denise, Venkataram Prasad, B. V., Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136532/
https://ncbi.nlm.nih.gov/pubmed/12208961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.19.9832-9843.2002
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