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A Single Mutation in the Carboxy Terminus of Reovirus Outer-Capsid Protein σ3 Confers Enhanced Kinetics of σ3 Proteolysis, Resistance to Inhibitors of Viral Disassembly, and Alterations in σ3 Structure

Mammalian reoviruses undergo acid-dependent proteolytic disassembly within endosomes, resulting in formation of infectious subvirion particles (ISVPs). ISVPs are obligate intermediates in reovirus disassembly that mediate viral penetration into the cytoplasm. The initial biochemical event in the reo...

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Udgivet i:J Virol
Principais autores: Wilson, Gregory J., Nason, Emma L., Hardy, Charles S., Ebert, Daniel H., Wetzel, J. Denise, Venkataram Prasad, B. V., Dermody, Terence S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136532/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12208961/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.19.9832-9843.2002
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